Is Cancer a Metabolic Disease?

Is Cancer a Genetic Disease or a Metabolic Disease?

Cancer is already the leading cause of death in Canada, the UK, Australia, New Zealand, and Denmark. In the US it is projected that cancer will surpass heart disease as the nation's leading killer by 2030. In 2015 more than 1.65 million Americans will be diagnosed with cancer and 590,000 will die from it (SEER, 2015). Currently nearly 15 million people in the US are either living with cancer or...

Cancer as a metabolic disease

Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supportin...

I-29: Steps to Cancer - Is Endometriosis a Potential Malignant Disease

Cancer as a mitochondrial metabolic disease

Cancer is widely considered a genetic disease involving nuclear mutations in oncogenes and tumor suppressor genes. This view persists despite the numerous inconsistencies associated with the somatic mutation theory. In contrast to the somatic mutation theory, emerging evidence suggests that cancer is a mitochondrial metabolic disease, according to the original theory of Otto Warburg. The findin...

Soy Isoflavone Genistein Is a Potential Agent for Metabolic Syndrome Treatment: A Narrative Review

Metabolic syndrome has a high prevalence (about 22.4% in adult individuals) in developed countries. Inflammation due to obesity and fat accumulation is the most important factor in the progression of metabolic syndrome. In cells which have a receptor for insulin hormone, inflammatory mediators target the insulin signaling pathway and cause insulin resistance. Peroxisome proliferator-activated r...